Diastereoselective Synthesis of γ-Amino Alcohols with Three Chiral Centers by Reduction of β-Amino Ketones and Derivatives

Article abstract of DOI:10.1021/jo00221a018

γ-Amino alcohols 4 with three chiral centers are obtained in very good yields by reduction of β-amino ketones 2 and β-acylamino ketones 3 with LiAlH4.The stereochemistry of the two diastereoisomers obtained in the reaction (4α and 4β) is unequivocally set