Journal of the Chemical Society. Perkin transactions I p. 825 - 830 (1985)
Update date:2022-08-04
Topics:
Atkinson, Robert S.
Gawad, Nagwa A.
The N-nitrenes generated by oxidation of N-aminoquinazolones (1) and (2) are trapped by the remote 2,4-dimethoxyphenyl ring.Oxidation of (1) in benzene gives the metacyclophane (3) in 60percent isolated yield whereas oxidation in methanol gives (5), (6) and (8).The structures of the acetal (5) and the imine (8) have been confirmed by X-ray crystallography.Oxidation of (2) in methanol yields (11) and (16).An explanation is offered for the selectivity for attack on the 2,3- or 5,6-double bonds of the dimethoxyphenyl ring by the N-nitrene derived from (1).
View MoreHubei Lingsheng Pharmaceuticals Co., Ltd.
Contact:+86-0710-3538058
Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
Suzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
YanCheng LongShen Chemical Co.,Ltd.
Contact:+86-515-86668866
Address:No.13,Weiyi Road,Funing Aoyang Industrial Park
Yicheng Goto Pharmaceuticals Co.,Ltd.
Contact:+86 710 3423122
Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
Jiangxi Province Bethel Pharmaceutical Co., Ltd.
Contact:+86-795-259 3456 ，+86-15957688008 13566650571
Address:Huangjindui Chemical Park， Shanggao County ，Yichun city，Jiangxi Province
Doi:10.1055/s-1985-31111
(1985)Doi:10.1007/BF00914989
(1961)Doi:10.1016/0022-328X(85)87380-0
(1985)Doi:10.1055/s-1985-31139
(1985)Doi:10.1246/bcsj.56.3694
(1983)Doi:10.3762/bjoc.15.66
(2019)
