PREPARATION OF α,β-DEHYDRO-β-AMINO ACID DERIVATIVES BY TIN-PROMOTED ADDITION OF MALONATES TO SIMPLE NITRILES.

Article abstract of DOI:10.1016/S0040-4039(00)98113-9

Simple alyphatic and aromatic nitriles undergo reaction with malonate esters in the presence of tin(lV) chloride to give derivatives of a α,β-dehydro-β-amino acids.The same products are obtained through use of bromomalonateesters.