Structure-Activity Studies of 5-alkyl>-3-methylisoxazoles: Inhibitors of Picornavirus Uncoating

DOI: 10.1021/jm00385a021

Source and publish data:

Journal of Medicinal Chemistry p. 383 - 388 (1987)

Update date:2022-08-03

Topics:

Authors:

Diana, Guy D.

Oglesby, Richard C.

Akullian, Vahan

Carabateas, Phillip M.

Cutcliffe, David

et al. et al.

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Article abstract of DOI:10.1021/jm00385a021

A series of substituted phenyl analogues of 5-<<4-(4,5-dihydro-2-oxazolyl)phenoxy>alkyl>-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes.Substituents in the 2-position greatly enhanced activi

Full text of DOI:10.1021/jm00385a021

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