Tetrahedron Letters p. 1619 - 1622 (1985)
Update date:2022-08-03
Topics: Alkylation Enantiomerically pure Chiral
Schultz, Arthur G.
McCloskey, Patrick J.
Sundararaman, Padmanabhan
Springer, James P.
The first method for preparation of enantiomerically pure aminocyclohexanes by Birch reduction-alkylation of a chiral anthranilic acid derivative is described; stereochemistry of alkylation is demonstrated by X-ray structural studies with 2b.
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