Tetrahedron Letters p. 2087 - 2088 (1998)
Update date:2022-08-02
Topics:
Czollner, Laszlo
Frantsits, Werner
Kueenburg, Bernhard
Hedenig, Ursula
Froehlich, Johannes
Jordis, Ulrich
A concise, scalable synthesis of (-)-galanthamine, a drug being used for the treatment of Alzheimer's disease, is described. The yield of the critical phenolic coupling step was optimized to 45-50%. For the reduction of the aryl bromide, air-activated LiAlH4 was used and racemic narwedine was converted to (-)-narwedine by a second order asymmetric transformation.
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