10.1002/anie.202015004
Angewandte Chemie International Edition
COMMUNICATION
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firmed by single crystal X-ray analysis of the corresponding mesyl
derivatives
9 and ent-9 (see, SI). This demonstartes that both
enantiomers of the racemic substarte could be accessed with this
catalytic KR process in good level of enantiomeric excess.
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[21] The selectivity factor (s) is calculated according to the following
equation:
s
=
ln[(1-c)(1-eeSM)]/ln[(1-c)(1+eeSM)], where the reaction
ee of product and eeSM = ee
conversion (c) = eeSM/(eeSM + eeP); eeP
=
of the recovered starting material. See Ref. [6] for more details.
[22] The hydrolysis of ester 6f afforded the ent-5fr with good enanti-
oselectivity. Absolute configuration of both 5fr and ent-5fr was con-
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