Enantioselective hydrolysis of cis-1,2-diacetoxycycloalkanedimethanols: enzymatic preparation of chiral building blocks from prochiral meso-substrates.

Article abstract of DOI:10.1016/S0040-4039(00)94782-8

The enzymatic hydrolysis of the prochiral title compounds 1a-f in presence of porcine liver esterase (PLE) and lipase from porcine pancreas (PPL) was studied, resulting in the preparation of the chiral monoacetates 2b-f with high (72-99percente.e.) enantiomeric purities.