
Tetrahedron Letters p. 755 - 758 (1999)
Update date:2022-09-26
Topics:
Granberg, Kenneth L.
Edvinsson, Karin M.
Nilsson, Kristina
The intermediates 3 and 4, useful in the preparation of new biologically active bafilomycin derivatives, were obtained via a thermal retro-aldol reaction in diphenyl ether. The starting materials 5 and 7 for the retro- aldol reaction were synthesized in a few steps from bafilomycin C1 (2) with or without a protective group at 7-OH.
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