Retro-aldol cleavage of bafilomycin derivatives

Article abstract of DOI:10.1016/S0040-4039(98)02365-X

The intermediates 3 and 4, useful in the preparation of new biologically active bafilomycin derivatives, were obtained via a thermal retro-aldol reaction in diphenyl ether. The starting materials 5 and 7 for the retro- aldol reaction were synthesized in a few steps from bafilomycin C₁ (2) with or without a protective group at 7-OH.