Journal of Medicinal Chemistry p. 4770 - 4778 (1992)
Update date:2022-09-26
Topics:
Capps, David B.
Dunbar, James
Kesten, Suzanne R.
Shillis, Joan
Werbel, Leslie M.
et al.
2-(Aminoalkyl)-5-nitropyrazolo<3,4,5-kl>acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with <(alkylamino)alkyl>hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.
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