Journal of Medicinal Chemistry p. 4770 - 4778 (1992)
Update date:2022-09-26
Topics:
Capps, David B.
Dunbar, James
Kesten, Suzanne R.
Shillis, Joan
Werbel, Leslie M.
et al.
2-(Aminoalkyl)-5-nitropyrazolo<3,4,5-kl>acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with <(alkylamino)alkyl>hydrazines.Impressive activity was demonstrated for the 9-hydroxy, 9-alkoxy, and 9-acyloxy analogs in vitro on a L1210 leukemia line and in vivo against the P388 leukemia.Advanced studies led to the selection of 3bbb for clinical trial.
View Moretaicang liyuan chemical co,.ltd
website:http://www.tcliyuanchem.com/productse.php
Contact:86-512-53539583
Address:Room 804,Huaxu Building,No.95,Renmin South Road,Taicang city,Jiangsu Province,China
Contact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Tianjin Ingenochem Technology Co.,Ltd
Contact:+86-22-23677060
Address:Hitech Green Industry Park K2-9-602, Nankai district
Shanghai Xinda Pharmaceuticals Co., Ltd.
Contact:86-21-33692333-8008
Address:999 Linxian Road, Jinshan Industrial Park, Shanghai, China
Wuhan Silworld Chemical Co.,Ltd
website:http://www.silworldchemical.com
Contact:+86-27-85613400
Address:No.198 jiangjun Road, Wuhan,China 430033
Doi:10.1016/S0040-4039(00)89231-X
(1985)Doi:10.1021/ja01367a034
(1930)Doi:10.1016/S0040-4020(01)96481-6
(1985)Doi:10.1248/cpb.33.944
(1985)Doi:10.1021/jo00225a032
(1985)Doi:10.1021/ja00312a088
(1985)
