Conformationally constrained renin inhibitory peptides: γ-lactam-bridged dipeptide isostere as conformational restriction

Article abstract of DOI:10.1021/jm00402a021

A model of the conformation of the enzyme-bound inhibitor of human renin suggested the possibility of a γ-lactam conformational restriction at the P₂-P₃ site. Synthetic routes to these γ-lactam dipeptide isosteres and their incorpora