Journal of Medicinal Chemistry p. 1369 - 1376 (1988)
Update date:2022-08-04
Topics: Conformational Restriction Isostere Conformationally constrained Renin inhibitory peptides
Thaisrivongs
Pals
Turner
Kroll
A model of the conformation of the enzyme-bound inhibitor of human renin suggested the possibility of a γ-lactam conformational restriction at the P2-P3 site. Synthetic routes to these γ-lactam dipeptide isosteres and their incorpora
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