A novel, highly efficient and selective desilylating method for trialkylsilyl ethers

Article abstract of DOI:10.1016/S0040-4039(98)01035-1

A series of tert-butyldimethylsilyl, tert-butyldiphenylsilyl and triisopropylsilyl ethers are hydrolyzed to theirs corresponding alcohols in CBr₄ / CH₃OH (0.1 eq. / 10mL) reaction system under refluxing condition. The chemoselectivity can be achieved between primary and secondary triisopropylsilyl ethers when more hindered 2-propanol is used instead of methanol.