One-pot synthesis of pyrimidine-5-carboxaldehyde and ethyl pyrimidine -5- carboxylate by utilizing pyrimidin-5-yl-lithium

Article abstract of DOI:10.1080/00397919408013824

Pyrimidine-5-carboxaldehyde was prepared in a one-pot reaction from 5- bromo-pyrimidine via metal halogen exchange. Pyrimidin-5-yl-lithium reacted with formate ester and ethyl cyanoformate, forming respectively the aldehyde and carboxy ethyl ester.

Full text of DOI:10.1080/00397919408013824

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Synthetic Communications: An
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One-Pot Synthesis of
Pyrimidine-5-Carboxaldehyde
and Ethyl Pyrimidine-5-
Carboxylate by Utilizing
Pyrimidin-5-yl-Lithium
Taikyun Rho a & Yahaya F. Abuh a
a Department of Medicinal Chemistry Center for
Drug Design and Development, College of Pharmacy,
The University of Toledo, Toledo, Ohio, 43606-3390
Available online: 23 Sep 2006
To cite this article: Taikyun Rho & Yahaya F. Abuh (1994): One-Pot Synthesis of
Pyrimidine-5-Carboxaldehyde and Ethyl Pyrimidine-5-Carboxylate by Utilizing
Pyrimidin-5-yl-Lithium, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 24:2, 253-256
To link to this article: http://dx.doi.org/10.1080/00397919408013824
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