Tetrahedron Letters p. 2859 - 2860 (1988)
Update date:2022-08-11
Topics:
Barluenga, Jose
Foubelo, Francisco
Fananas, Francisco J.
Yus, Miguel
The successive reaction of 2-chloroethylbenzamide with n-butyl-lithium and lithium naphthalenide at -78 deg C leads to N-lithio-N-(2-lithioethyl)benzamide, which reacts with different electrophiles (H2O, D2O, Me2S2, CO2, i-PrCHO, PhCHO, Me2CO, Ph2CO) to afford the expected 2-functionalized benzamides.
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