An improved preparation of a tertiary alcohol proline linker and its use in a synthesis of mosquito oostatic hormone

Article abstract of DOI:10.1016/S0040-4039(00)74702-2

An improved synthesis of 4-(3'-hydroxy-3'-methylbutyl)phenoxyacetic acid was developed using THF to overcome solubility problems initially encountered in trying to reproduce the published preparation. This hydroxyacid linker was coupled to aminomethyl polystyrene resin and used for a synthesis of the mosquito oostatic hormone by the Fmoc protocol. Attempts to prepare this insect peptide by other techniques had failed because of loss of cyclo-Pro₂ from the resin.