2,4,6-Trichloropyrimidine. Reaction with sodium amide

Article abstract of DOI:10.1002/jhet.5570360524

The first reaction between 2,4,6-trichloropyrimidine 1 and anionic nitrogen nucleophiles is described. Treatment of 1 with one equivalent of sodium amide gave mixtures of 4-amino-2,6-dichloropyrimidine 2 and 2-amino- 4,6-dichloropyrimidine 3. Additional quantities of sodium amide failed to provide either diamino- or triaminopyrimidines. Instead, the strongly basic nature of sodium amide led to higher molecular products that were not characterized.