A practical stereoselective synthesis of (2S, 3S)-3-hydroxyleucine

Article abstract of DOI:10.1016/0040-4039(95)01456-R

A practical and convenient procedure is described for the preparation of gram quantities of (2S, 3S)-3-hydroxyleucine. The key step involves the triflate-mediated cyclization of spirooxazolidine 4 to the spirobicyclic compound 5, which is easily converted to the title compound in high yield.