Synthesis, in vitro evaluation and molecular docking studies of biscoumarin thiourea as a new inhibitor of α-glucosidases

DOI: 10.1016/j.bioorg.2015.09.004

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Bioorganic Chemistry p. 36 - 44 (2015)

Update date:2022-08-11

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Authors:

Zawawi, Nik Khairunissa Nik Abdullah

Taha, Muhammad

Ahmat, Norizan

Ismail, Nor Hadiani

Wadood, Abdul

Rahim, Fazal

Rehman, Ashfaq Ur

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Article abstract of DOI:10.1016/j.bioorg.2015.09.004

Biscoumarin analogs 1-18 have been synthesized, characterized by EI-MS and ¹H NMR and evaluated for α-glucosidase inhibitory potential. All compounds showed variety of α-glucosidase inhibitory potential ranging in between 13.5 ± 0.39 and 104.62

Full text of DOI:10.1016/j.bioorg.2015.09.004

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