Asymmetrische Katalyse III. Synthese, spektroskopische Untersuchungen und katalytische Wirkung eines neuen chiralen Phosphanliganden

Article abstract of DOI:10.1016/0022-328X(93)83228-N

The reduction of 3,4-bis(dimenthylphosphino)maleic anhydride (2) with LiAlH4 yields a new optically-active P-ligand, the chiral γ-lactone 3.The structure of 3 was determined by 1H, 13C and 31P-NMR spectroscopy, and X-ray crystal structure analysis.This ligand is used as co-catalyst with BF4 in the catalytic hydrogenation of α-acetamidocinnamic acid and methyl α-acetamidocinnamate.Optical yields of up to 75percent were obtained with the ester.