A General Synthesis of Aromatic Compounds Carrying Two Neopentyl Groups on Adjacent Positions

Article abstract of DOI:10.1016/S0040-4039(00)77012-2

3,4-Dineopentylthiophene (4) was synthesized in a good overall yield starting frm methyl neopentyl ketone. 3,4-Dineopentylthiophene-1,1-dioxide (5a), easily obtainable by oxidation of 4, undergoes Diels-Alder reactions with a variety of acetylenic dienophiles or their equivalent to furnish aromatic compounds carrying two neopentyl groups on adjacent positions.