Stereoselective Reactions. 14.Efficient Enantioselective Construction of Quaternary Carbon Centers by the Sequential Dialkylation of (S)-γ--γ-butyrolactone. Synthesis of Optically Active β,β-Disubstituted γ-Butyrolactones.

DOI: 10.1021/jo00252a039

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Journal of Organic Chemistry p. 4094 - 4098 (1988)

Update date:2022-08-17

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Authors:

Tomioka, Kiyoshi

Cho, Youn-Sang

Sato, Fuminori

Koga, Kenji

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Article abstract of DOI:10.1021/jo00252a039

Sequential dialkylation of the lithium enolate, generated from (S)-γ-<(trityloxy)methyl>-γ-butyrolactone (1), with two different alkyl halides created chiral quaternary carbon centers with extremely high diastereoface selection.A unique conformation of 1,

Full text of DOI:10.1021/jo00252a039

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