Synthesis of N-t-Butoxycarbonyl-4,4-dideuterio-L-proline

Article abstract of DOI:10.1055/s-1986-31487

The title compound, which is useful for structural investigations of proline-containing peptides by 1H-N.M.R. spectroscopy, has been synthesized in five simple steps from N-t-butoxycarbonyl-4-hydroxyproline and designed for a maximal deuterium incorporation.The deuterium content was nearly 90percent.