Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant

DOI: 10.1016/j.bmc.2021.116039

Source and publish data:

Bioorganic and Medicinal Chemistry (2021)

Update date:2022-08-17

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Authors:

Fukuda, Tsutomu

Anzai, Mizuho

Nakahara, Akane

Yamashita, Kentaro

Matsukura, Kazuaki

Ishibashi, Fumito

Oku, Yusuke

Nishiya, Naoyuki

Uehara, Yoshimasa

Iwao, Masatomo

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Article abstract of DOI:10.1016/j.bmc.2021.116039

Azalamellarin N, a synthetic lactam congener of the marine natural product lamellarin N, and its A-ring-modified analogues were synthesized and evaluated as potent and non-covalent inhibitors of the drug-resistant epidermal growth factor receptor T790M/L8

Full text of DOI:10.1016/j.bmc.2021.116039

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Product name:N-(3,4-dimethoxyphenyl)-Carbamic acid 1,1-dimethylethyl ester

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