Pyrrole and Pyrazole Ring Closure in Heterogeneous Media

Article abstract of DOI:10.1055/s-1986-31655

Pyrroles and pyrazoles may be conveniently prepared by dispersing primary amines or hydrazines and 1,4- or 1,3-diketones, respectively, on alumina or clay (montmorillonite K 10) without solvent, keeping the mixture at 20 deg C or higher temperatures for 1-26 h, and then eluting the product with dichloromethane.