Two novel triterpenoid pentasaccharides with an unusual glycosyl glycerol side chain from Ardisia crenata

Article abstract of DOI:10.1016/S0040-4020(01)89300-5

Two novel triterpenoid pentasaccharides, ardisicrenosides E and F, were isolated from the roots of Ardisia crenata. They are the first examples of a triterpenoid glycoside hybridized with a glycosyl glycerol. Their structures were mainly established on the basis of high field NMR studies. In addition, molecular mechanics and dynamics calculation studies showed that the lack of ¹³C glycosylation shifts in the Rhamα1 →2G'Icβ and G'lcβ1→4Araα fragments in ardisicrenoside E could be correlated with the distortion of the corresponding torsion angles. Both compounds exhibited moderate inhibitory activity on cAMP phosphodiesterase.