High yields of meta-substituted amination products in the S(N)Ar substitution of benzenes

DOI: 10.1016/S0040-4039(98)02570-2

Source and publish data:

Tetrahedron Letters p. 1219 - 1222 (1999)

Update date:2022-08-16

Topics:

Authors:

Brown Brown

Foubister

Ratcliffe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)02570-2

Morpholine substitution in fluorobenzenes containing a meta-substituted electron withdrawing group proceeds in DMSO at 100 °C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%.

Full text of DOI:10.1016/S0040-4039(98)02570-2

Products guided by the article

Product name:4-(4-CYANOPHENYL)MORPHOLINE

Cas No:10282-31-2

R&D Labs maybe for 10282-31-2

Jiangsu King Road New Materials Co., Ltd.

website:http://www.jskingroad.com

Contact:0519-85720726 0519-85720721 13584535752

Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
Ceresking Ecology & Technology co.,ltd

Contact:86 22 66218397

Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
Shanghai Send Pharmaceutical Technology Co., Ltd.

website:http://www.shsendpharma.com

Contact:021-58088081, +8613585868794

Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
Changyi Xinxing Technology Development Co., Ltd.

Contact:0086-510-86651065(Time Zone:8),86651656

Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Acros Pharmatech Limited

website:http://www.acrospharmatech.com

Contact:+1-3234804688

Address:Flat/RM 1502,Easey Commercial building 253-261 Hennessy Road,Wanchai，HongKong

Relevant to this article

Facile Beckmann rearrangement of ketoximes mediated by yttrium triflate

Doi:10.1080/00304940409458685
(2004)
An experimental and theoretical high temperature kinetic study of the thermal unimolecular dissociation of fluoroethane

Doi:10.1039/b808168a
(2008)
Intramolecular Hydrogen-bond Controlled Unidentate Co-ordination of Potentionally Chelating N-Acyl-N'-alkylthioureas: Crystal Structure of cis-Bis(N-benzoyl-N'-propylthiourea)dichloroplatinum(II)

Doi:10.1039/DT9930002071
(1993)
The study of phosphoramidite as O-phosphitylation agent and its reactivity

Doi:10.1080/10426500008045253
(2000)
Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies

Doi:10.1016/j.ejmech.2015.01.009
(2015)
4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: A new practical synthesis and biological activity

Doi:10.1016/j.tetlet.2014.10.057
(2014)

Article Doi