High yields of meta-substituted amination products in the S(N)Ar substitution of benzenes

DOI: 10.1016/S0040-4039(98)02570-2

Source and publish data:

Tetrahedron Letters p. 1219 - 1222 (1999)

Update date:2022-08-16

Topics:

Authors:

Brown Brown

Foubister

Ratcliffe

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Article abstract of DOI:10.1016/S0040-4039(98)02570-2

Morpholine substitution in fluorobenzenes containing a meta-substituted electron withdrawing group proceeds in DMSO at 100 °C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%.

Full text of DOI:10.1016/S0040-4039(98)02570-2

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