High yields of meta-substituted amination products in the S(N)Ar substitution of benzenes

DOI: 10.1016/S0040-4039(98)02570-2

Source and publish data:

Tetrahedron Letters p. 1219 - 1222 (1999)

Update date:2022-08-16

Topics:

Authors:

Brown Brown

Foubister

Ratcliffe

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)02570-2

Morpholine substitution in fluorobenzenes containing a meta-substituted electron withdrawing group proceeds in DMSO at 100 °C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%.

Full text of DOI:10.1016/S0040-4039(98)02570-2

Products guided by the article

Product name:4-(4-CYANOPHENYL)MORPHOLINE

Cas No:10282-31-2

R&D Labs maybe for 10282-31-2

Shanghai KFSL Pharmaceutical Technology Co.,Ltd.

Contact:+86-21-39971718

Address:859 jiadingchengliu shanghai
Hubei Vanz Pharm Co.,Ltd

website:http://www.vanzpharm.com/en/index.html

Contact:86-27-84492310

Address:FANHU INDUSTRY PARK
Wuxi Innopal International Trade CO.,LTD

Contact:+86-510-80711901-8003

Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Anhui Hope-Chem Co., Ltd.

Contact:86-551-63540590

Address:No 1388 Furong Rd., Hefei, Anhui, China
hangzhou verychem science and technology co.ltd

website:http://www.verypharm.com

Contact:+86-571-88162785; 88162786

Address:F1502, 753 Shenhua road, Hangzhou, China

Relevant to this article

Facile Beckmann rearrangement of ketoximes mediated by yttrium triflate

Doi:10.1080/00304940409458685
(2004)
An experimental and theoretical high temperature kinetic study of the thermal unimolecular dissociation of fluoroethane

Doi:10.1039/b808168a
(2008)
Intramolecular Hydrogen-bond Controlled Unidentate Co-ordination of Potentionally Chelating N-Acyl-N'-alkylthioureas: Crystal Structure of cis-Bis(N-benzoyl-N'-propylthiourea)dichloroplatinum(II)

Doi:10.1039/DT9930002071
(1993)
The study of phosphoramidite as O-phosphitylation agent and its reactivity

Doi:10.1080/10426500008045253
(2000)
Synthesis of novel inhibitors of α-glucosidase based on the benzothiazole skeleton containing benzohydrazide moiety and their molecular docking studies

Doi:10.1016/j.ejmech.2015.01.009
(2015)
4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: A new practical synthesis and biological activity

Doi:10.1016/j.tetlet.2014.10.057
(2014)

Article Doi