High yields of meta-substituted amination products in the S(N)Ar substitution of benzenes

Article abstract of DOI:10.1016/S0040-4039(98)02570-2

Morpholine substitution in fluorobenzenes containing a meta-substituted electron withdrawing group proceeds in DMSO at 100 °C over 60 h to give meta-substitution products (by fluoride ion displacement) in pure isolated yields of 19-98%.