Improved procedure for N-formylation of amines to formamides using formic acid, oxalyl chloride and imidazole

DOI: 10.1248/cpb.42.1931

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1931 - 1934 (1994)

Update date:2022-08-28

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Authors:

Kitagawa

Ito Ito

Tsutsui Tsutsui

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Article abstract of DOI:10.1248/cpb.42.1931

The reaction of imidazole (15) with formyl chloride (14), generated in situ by the action of oxalyl chloride (10) on formic acid (3), afforded N-formylimidazole (7), which is a convenient formylating reagent. This procedure was used to prepare N-formyl derivatives (2) of aliphatic, aromatic and heteroaromatic amines (1) under mild conditions.

Full text of DOI:10.1248/cpb.42.1931

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