Large scale preparation of (2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane: A key building block for HIV-protease inhibitors

Article abstract of DOI:10.1016/0040-4039(95)00533-I

(2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane is prepared in four steps from commercially available N,N-dimethyl-L-phenylalaninol. The synthesis is amenable to the preparation of kilogram quantities of enantiomerically pure material.