α-Amino acid derived bisphosphonates. Synthesis and anti-resorptive activity

Article abstract of DOI:10.1080/10426500108045257

Eleven new bisphosphonates were prepared from naturally-occurring l-amino acids. The synthesis required special attention to amino and side-chain protections. The novel compounds were tested in TPTX (thyroparathyroidectomized) rats against arotinoid-induced hypercalcemia and were compared to alendronate. Most of the compounds showed moderate to no anti-resorptive activity. Two compounds were more active than clodronate, but less than alendronate. Limited SAR conclusions were drawn.

Full text of DOI:10.1080/10426500108045257

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Phosphorus, Sulfur, and Silicon
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α-AMINO ACID DERIVED
BISPHOSPHONATES. SYNTHESIS
AND ANTI-RESORFTIVE
ACTIVITY
Dana M. Mizrahi a , Trevor Waner a & Yoffi Segall a
a Department of Organic Chemistry, Israel Institute
for Biological Research, P.O. Box 19, Ness-Ziona,
74100, Israel
Version of record first published: 04 Oct 2006.
To cite this article: Dana M. Mizrahi, Trevor Waner & Yoffi Segall (2001): α-AMINO
ACID DERIVED BISPHOSPHONATES. SYNTHESIS AND ANTI-RESORFTIVE ACTIVITY,
Phosphorus, Sulfur, and Silicon and the Related Elements, 173:1, 1-25
To link to this article: http://dx.doi.org/10.1080/10426500108045257
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