Studies on Prodrugs. 5. Synthesis and Antimicrobial Activity of N-(Oxoalkyl)norfloxacin Derivatives

DOI: 10.1021/jm00160a037

Source and publish data:

Journal of Medicinal Chemistry p. 2020 - 2024 (1986)

Update date:2022-08-31

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Authors:

Kondo, Hirosato

Sakamoto, Fumio

Kodera, Yasuo

Tsukamoto, Goro

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Article abstract of DOI:10.1021/jm00160a037

Several N-(oxoalkyl)norfloxacin derivatives (3a-g) were synthesized and evaluated for antibacterial activity in vitro and in vivo.Most of the compounds exhibited in vitro activity comparable to that of norfloxacin for Gram-positive bacteria, whereas their

Full text of DOI:10.1021/jm00160a037

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