European Journal of Medicinal Chemistry p. 969 - 974 (1993)
Update date:2022-08-11
Topics:
Caliendo, G.
Carlo, R. Di
Meli, R.
Perissutti, E.
Santagada, V.
et al.
A series of 1- and 2-<3-<4-(X)-1-piperazinyl>-propyl>benzotriazoles were prepared and evaluated for their trazodone-like pharmacological profile; as preliminary pharmacological screening, the compounds were tested for their antiserotonergic, antiadrenergic and antihistaminic in vitro activity as well as for their analgesic in vivo action.Structure-activity relationships showed that among the synthesized compounds, the analogues bearing on the 4-piperazine nitrogen either an unsubstituted phenyl ring or a 2- or 3-chloro phenyl moiety show a pharmacological profilesimilar to that of the antidepressant trazodone. benzotriazoles / antiserotonergic / antiadrenergic / antihistaminic/ analgesic
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