Tetrahedron p. 5105 - 5110 (1986)
Update date:2022-08-10
Topics:
Brown, John M.
Cook, Stephen J.
Khan, Riaz
Rhodium complexes of the ligand αα-TREDIP give 62:1 iso-regioselectivity in the hydroformylation of styrene under ambient conditions without excess posphine, higher than any previously reported value.The results are compared with those obtained with other ligands, and extended to preparation of 2-(6-methoxy-2-naphthyl)-propanal, a precursor of the anti-inflammatory drug naproxen.
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