Chemical and Pharmaceutical Bulletin p. 1191 - 1197 (1994)
Update date:2022-08-18
Topics:
Matsumoto
Takeda
Iwata
Sakamoto
Ishida
Racemic 1-acetoxy-2-phenylpropane (12) and 1-acetoxy-2-(2- naphthyl)propane (33) were hydrolyzed with lipase at 35-36°C for 2 and 24 h to give predominantly (S)-2-phenyl-1-propanol (11) and (S)-2-(2-naphthyl)-1- propanol (32), respectively. However, racemic 1-acetoxy-2-(1-naphthyl)propane (25) was recovered intact even when the reaction was carried out for 240 h. On the other hand, the enantioselectivities towards racemic 2-phenyl (16), 2- (p-tolyl) (20), 2-(1-naphthyl) (28), and 2-(2-naphthyl) (36) derivatives of 1-acetoxy-2-propanol were very low.
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Doi:10.1016/S0040-4039(00)92123-3
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