Efficient stereoselective synthesis of dolastatin 10, an antineoplastic peptide from a sea hare

Article abstract of DOI:10.1016/S0040-4039(00)92123-3

The stereoselective and efficient synthetic route to dolastatin 10, an antineoplastic peptide from a sea hare, has been developed. Dolaproine, one of the unusual constituents, was prepared in a highly stereoselective manner by the Evans aldol methodology.