Journal of the Korean Chemical Society p. 240 - 242 (2011)
Update date:2022-08-16
Topics:
Keetha, Laxminarayana
Palle, Sadanandam
Ramanatham, Vinodkumar
Khagga, Mukkanti
Chinnapillai, Rajendiran
A large scale and commercially feasible synthesis of 5-chloroindole and its 3-substituted analogues has been described via a halogen - halogen exchange reaction from 5-bromoindole and its derivatives using cuprous chloride and dipolar aprotic solvent N-methyl-2-pyrrolidone in one pot with good yields.
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