Copper-assisted substitution reaction for phenylthio group of a 4- phenylthioazetidinone derivative

Article abstract of DOI:10.1016/S0040-4039(00)78210-4

The phenylthio group of 4-phenylthioazetidinone (1) was readily substituted with copper(I) salts of carboxylates, thiocarboxylates, and copper(I) enolates of malonates and β-ketoesters to give synthetic intermediates (3 and 4) for penem and carbapenem antibiotics.