Preparation of ethyl (R)-3-hydroxy-4-chlorobutyrate by selective reduction of (R)-4-(trichloromethyl)-oxetan-2-one: Key intermediate to (R)-carnitine and (R)-4-amino-3-hydroxybutyric acid

Article abstract of DOI:10.1080/00397919708003044

Selective reduction of (R)-4-(trichloromethyl)-oxetan-2-one in ethanol by catalytic hydrogenation on Pd-C in the presence of KOAc gave directly ethyl (R)-3-hydroxy-4-chlorobutyrate, which can be used as a key intermediate for the synthesis of some biologically active γ-amino-β-hydroxy amino acids, (R)-carnitine and γ-amino-β-hydroxy amino acid (R)-GABOB).

Full text of DOI:10.1080/00397919708003044

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Synthetic Communications: An
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Preparation of Ethyl (R)-3-
hydroxy-4-chlorobutyrate by
Selective Reduction of (R)-4-
(Trichloromethyl)-oxetan-2-
one: Key Intermediate to (R)-
Carnitine and (R)-4-Amino-3-
hydroxybutyric Acid
Choong Eui Song a , Jae Kyun Lee a , In O Kim a &
Jung Hoon Choi b
a Division of Applied Science , Korea Institute of
Science and Technology , P.O.Box 131, Cheongryang,
Seoul, 130-650, Korea
b Department of Chemistry , Hanyang University ,
Seoul, 133-791, Korea
Published online: 22 Aug 2006.
To cite this article: Choong Eui Song , Jae Kyun Lee , In O Kim & Jung Hoon Choi
(1997) Preparation of Ethyl (R)-3-hydroxy-4-chlorobutyrate by Selective Reduction of
(R)-4-(Trichloromethyl)-oxetan-2-one: Key Intermediate to (R)-Carnitine and (R)-4-
Amino-3-hydroxybutyric Acid, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 27:6, 1009-1014, DOI:
10.1080/00397919708003044
To link to this article: http://dx.doi.org/10.1080/00397919708003044

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