Enantioselective hydrogenation of ethyl 4-chloro-3-oxobutyrate in solutions of organic salts with recycling of the catalyst Ru-BINAP

Article abstract of DOI:10.1007/s11172-005-0092-z

Enantioselective hydrogenation of ethyl 4-chloro-3-oxobutyrate in ionic liquid systems containing tetraethylammonium bromide, 1-butyl-3- methylimidazolium hexafluorophosphate, or 1-butyl-3-methylimidazolium trifluoromethanesulfonate in the presence of the chiral catalyst Ru-BINAP ensures a high level of asymmetric induction after at least threefold recycling of the catalyst.