Regiospecific opening of 1,2-epoxides with acetone cyanohydrin under mildly basic conditions

DOI: 10.1016/S0040-4039(00)92067-7

Source and publish data:

Tetrahedron Letters p. 3281 - 3284 (1992)

Update date:2022-08-10

Topics:

Authors:

Mitchell

Koenig Koenig

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Article abstract of DOI:10.1016/S0040-4039(00)92067-7

Acetone cyanohydrin with stoichiometric triethylamine opens epoxides regiospecifically to give β-hydroxy nitriles. As expected, addition of cyanide occurs at the least substituted carbon.

Full text of DOI:10.1016/S0040-4039(00)92067-7

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