Enantioselective synthesis of cyclopropane α-amino acids: Synthesis of N-Boc-cis-(2S,3R,4S)-3,4-methanoproline and N-Boc-(2S,3R,4S)-3,4-methanoglutamic acid

Article abstract of DOI:10.1016/0040-4039(95)00482-R

The title compounds were synthesized by a 5-step facile transformation of the key intermediate 4, itself obtained by a 'one-pot' sulfone-mediated cyclopropanation from chiral synthon (R)-1 and (2R)-glycidyl triflate.