Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

DOI: 10.1016/j.ejmech.2016.04.004

Source and publish data:

European Journal of Medicinal Chemistry p. 170 - 177 (2016)

Update date:2022-08-10

Topics:

Authors:

Esvan, Yannick J.

Zeinyeh, Wael

Boibessot, Thibaut

Nauton, Lionel

Théry, Vincent

Knapp, Stefan

Chaikuad, Apirat

Loa?c, Nadège

Meijer, Laurent

Anizon, Fabrice

Giraud, Francis

Moreau, Pascale

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Article abstract of DOI:10.1016/j.ejmech.2016.04.004

The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaroma

Full text of DOI:10.1016/j.ejmech.2016.04.004

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