Studies on the Susceptibility to Alkaline Hydrolysis of Inclusion Complexes of Organophosphorothioate Pesticides with β-Cyclodextrins

Article abstract of DOI:10.1002/ps.2780410404

The inhibition of alkaline hydrolysis of organophosphorothioate pesticides such as parathion, parathion-methyl and fenitrithion by the formation of inclusion complexes with β-cyclodextrin and its methylated derivatives was investigated. The inclusion complex/pesticide stability relationship with the series of pesticides and β-cyclodextrins is discussed in connection with the inclusion geometrical parameters, such as those relating to the inclusion orientation and depth of the 4-nitrophenoxy moiety of the included pesticide. These parameters were estimated from the induced circular dichroism of the inclusion complexes by means of the rotational-strength analysis method.