Tetrahedron p. 2649 - 2656 (1988)
Update date:2022-08-17
Topics:
Fleet, George W. J.
Son, Jong Chan
Green, Donovan St. C.
Bello, Isabelle Cenci di
Winchester, Bryan
The syntheses of 1,4-dideoxy-1,4-imino-L-ribitol and of 1,4-dideoxy-1,4-imino-D-talitol from D-mannose are described. 1,4-Dideoxy-1,4-imino-D-talitol is a specific and competitive inhibitor of human liver α-mannosidase in vitro and also blocks the lysosomal catabolism of asparigine-linked glycans of glycoproteins in vivo.
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(2020)Doi:10.1007/s10593-017-2132-7
(2017)Doi:10.1021/ja01857a036
(1941)
