Rate of deprotonation of a simple ketone by lithium diisopropylamide

Article abstract of DOI:10.1016/S0040-4039(98)00015-X

Rate studies on deprotonation of a simple ketone (R-2,2,6- trimethylcyclohexanone) with lithium diisopropylamide are described. The data are consistent with the reaction being first order in ketone and half order in the base, corresponding to the rate equation: v = k[ketone][LDA](1/2).