An efficient synthesis of 4-hydroxy-1H-indole-2-carbonitrile and its conversion to DPI 201-106

Article abstract of DOI:10.1080/00397919508011384

A three-step synthesis of 4-hydroxy-1H-indole-2-carbonitrile (3) from commercially available 1,5,6,7-tetrahydro-4H-indol-4-one (4) via cyanation and subsequent halogenation/dehydrohalogenation proceeds in 84% overall yield. The conversion of 3 into positive inotrope DPI 201-106 (1) is also described.

Full text of DOI:10.1080/00397919508011384

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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An Efficient Synthesis of
4-Hydroxy-1H-indole-2-
carbonitrile and Its Conversion
to DPI 201–106
Kimberly G. Estep a
a Department of Medicinal Chemistry, Sterling
Winthrop Pharmaceuticals Research Division,
Sterling Winthrop Inc., Collegeville, PA, 19426-0900
Available online: 23 Sep 2006
To cite this article: Kimberly G. Estep (1995): An Efficient Synthesis of 4-Hydroxy-1H-
indole-2-carbonitrile and Its Conversion to DPI 201–106, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 25:4,
507-514
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