Asymmetric catalytic cyanosilylation of aldehydes using a chiral binaphthol-titanium complex

Article abstract of DOI:10.1016/S0040-4039(97)01432-9

The asymmetric catalytic cyanosilylation of aliphatic aldehydes with Me₃SiCN using (R)-BINOL-Ti(O-i-Pr)₂ as an asymmetric precatalyst is shown to proceed smoothly in dichloromethane to afford the cyanohydrins in relatively high enantioselectivity (up to 75% ee).