Bioorganic and medicinal chemistry letters (2020)
Update date:2022-08-11
Topics:
Hoppe, Heinrich C.
Isaacs, Michelle
Kaye, Perry T.
Krause, Rui W. M.
Manyeruke, Meloddy H.
Seldon, Ronnett
Tshiwawa, Thendamudzimu
Warner, Digby F.
A series of N2,N2′-bis[4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccino-hydrazides, containing 4-hydroxycoumarin, hydrazine and tartaric acid moieties, have been prepared and examined for possible biological activity. Several of these compounds exhibit promising HIV-1 integrase inhibition (IC50 = 3.5 μM), and anti-T. brucei (32% viability) and anti-mycobacterial (Visual MIC90 = 15.63 μM) activity.
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Doi:10.1021/jo00366a048
(1986)Doi:10.1021/ja306934b
(2012)Doi:10.1021/acsmedchemlett.8b00158
(2018)Doi:10.1039/c39790000145
(1979)Doi:10.1016/S0040-4020(01)90322-9
(1987)Doi:10.1021/bi4002437
(2013)