Novel protein kinase C inhibitors: α-terthiophene derivatives

Article abstract of DOI:10.1016/S0960-894X(98)00468-5

A series of α-terthiophene derivatives were prepared and their protein kinase C inhibitory activity were evaluated. The aldehyde derivatives were most potent inhibitors (IC₅₀ < 1 μM). 2a-Terthiophene monoaldehyde was inactive in the inhibitions of protein kinase A, mitogen activated protein kinase and protein tyrosine kinase.