Selective Mono-Alkylation and Arylation of Dichlorobenzenes by Palladium-Catalyzed Grignard Cross-Coupling

Article abstract of DOI:10.1246/cl.1991.2073

Palladium(II)-phosphine complexes, especially PdCl2(dppf) where dppf stands for 1,1'-Bis(diphenylphosphino)ferrocene, are effective catalysts for the cross-coupling of Grignard reagents with dichlorobenzenes to produce selectively mono-alkylated and arylated benzenes.The addition of ligands is also effective for the cross-coupling of Grignard reagents containing a β-hydrogen(s).