Synthesis of (2S,3S)-[3-2H1]- and (2S,3R)-[2,3-2H2]-proline

Article abstract of DOI:10.1016/S0040-4039(00)73933-5

Discovery of conditions for intramolecular trapping of a ketene intermediate has led to an effective synthesis of samples of the amino acid proline which are stereospecifically labelled on the β-carbon. Since samples of stereospecifically labelled pyroglutamic acid derivatives are prepared in the route, other stereospecifically labelled, biologically important amino acids may be accessed by the synthesis.